Written by : Dr.M.D.Mazumdar, MD
Lobular Carcinoma In Situ (LCIS) is a type of abnormal cell change which starts in the cells of a part of the breast known as the 'lobules'.
The normal brest anatomy consists mainly of milk-producing lobules and ducts to carry the milk. Each breast has about 20 lobules which are drained by ducts to carry the milk to the nipples.
LCIS develops in these lobules but does not break through the basement membrane to spread to the surrounding tissue.
'In situ' is a Latin word meaning 'in place'. LCIS is also referred to as TIS, which means 'tumor in situ' or 'in the same place'.
LCIS is not a cancer but a precancerous condition. Presence of LCIS indicates that the woman is at a higher risk of developing invasive lobular breast carcinoma (ILC) in later life. So, some researchers prefer the term 'lobular neoplasia' instead of 'lobular carcinoma'. A neoplasia is a collection of abnormal cells.
About 25% of women with LCIS will develop ILC. Time to invasive lobular breast carcinoma (ILC) after initial diagnosis of LCIS on biopsy is usually 15 - 30 years.
Lobular breast carcinoma is the second most common type of breast cancer. It is less common than invasive ductal breast cancer and more common than other types of breast cancers like Inflammatory Breast cancer and Paget's Disease of the Breast .
LCIS commonly occurs at around the the ages of 40 and 50 years. It is more common before menopause has occured and is extremely rare in men.
Breast Cancer Screening guidelines for women with LCIS.
Stages of LCIS:
LCIS is generally considered to be Stage O of Breast cancer since it is non-invasive, although many researchers prefer to think of it as a marker for breast cancer rather than a true precursor of breast cancer.
Read More :
Treatment of LCIS
Diagnosis of LCIS